Liver injury induced by paracetamol and challenges associated with intentional and unintentional use A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Too Much of a Good Thing: Inadvertent Acetaminophen Overdose in a Low Weight, Elderly Patient What are the potential side effects and risks of overdose with oral glutathione (GSH) tablets?